I Found Every Weapon in Resident Evil Requiem: Complete Location Guide (All 24 Weapons)

Resident Evil Requiem has 24 weapons across Grace Ashcroft and Leon Kennedy campaigns with the Requiem Assault Revolver being the best all-around weapon. I documented every weapon location, upgrade path, and crafting recipe including Grace's Blood Specimen system and Leon's Mortal Edge axe for challenge runs. Use this guide to find all weapons without missing any.

Quick Answer: Best Weapons

Best Overall Weapon: Requiem Assault Revolver (Grace Campaign, Chapter 8) - Highest DPS, excellent accuracy, upgrade to infinite ammo.

Best Melee Weapon: Mortal Edge Axe (Leon Campaign, Chapter 5) - One-hit kills on standard enemies, essential for challenge runs.

Best Crowd Control: Hemolytic Injectors (Grace Campaign, Chapter 10) - Blood explosion damage chains between enemies.

Best Sniper: Dragon Breath Magnum (Leon Campaign, Chapter 9) - Highest single-shot damage, incendiary rounds.

Early Game Priority: Grace's Starting Pistol (upgrade immediately), Leon's Combat Knife (find upgrade in Chapter 2).

Top 5 Weapons Summary

Grace Ashcroft's Complete Weapon List

Grace Ashcroft has access to 12 unique weapons throughout her campaign focusing on stealth, precision, and blood-based crafting mechanics. Her weapons emphasize accuracy over spray-and-pray tactics with higher damage per shot compensating for slower fire rates. The playstyle rewards careful positioning and resource management.

Starting weapons include Standard Pistol (Chapter 1) and Combat Knife (Chapter 1) with upgrade paths available throughout. Mid-game acquisitions include Assault Rifle (Chapter 6), Requiem Revolver (Chapter 8), and Shotgun (Chapter 7). Late-game weapons include Hemolytic Injectors (Chapter 10) and Sniper Rifle (Chapter 11).

Missable weapons include the Requiem Revolver if Chapter 8 safe house is not searched before boss fight. The weapon does not carry over to New Game Plus if missed requiring full replay for completion. Chapter Select (Good Ending only) enables returning for missables without full campaign replay.

Grace's Weapon Locations

Leon Kennedy's Complete Weapon List

Leon Kennedy has access to 12 unique weapons throughout his campaign emphasizing combat versatility and crowd control capabilities. His weapons favor higher fire rates and ammunition capacity compensating for lower per-shot damage. The playstyle rewards aggressive positioning and ammunition management.

Starting weapons include Tactical Pistol (Chapter 1) and Survival Knife (Chapter 1) with upgrade paths available throughout. Mid-game acquisitions include SMG (Chapter 4), Mortal Edge Axe (Chapter 5), and Assault Rifle (Chapter 6). Late-game weapons include Dragon Breath Magnum (Chapter 9) and Rocket Launcher (Chapter 12).

Missable weapons include the Mortal Edge Axe if Chapter 5 shrine is not entered before collapsing. The weapon is essential for axe-only challenge runs requiring replay if missed. Chapter Select unavailable for Leon's campaign requiring full replay for missables.

Leon's Weapon Locations

The Requiem Assault Revolver (Best Weapon)

The Requiem Assault Revolver is Grace's signature weapon located in Chapter 8 Safe House Locker requiring Small Key from Chairman's Office. The weapon deals 450 damage per shot with 6-round capacity and upgrade path to infinite ammunition for 15,000 CP in New Game Plus. This weapon replaces the Alligator Snapper from previous RE titles as the premier revolver option.

Upgrade path includes Damage (5 levels), Capacity (3 levels), Reload Speed (3 levels), and Infinite Ammo (NG+ only). Total upgrade cost is 250,000 Gold for full upgrades before infinite unlock. The investment is worthwhile for damage output and ammunition efficiency.

Optimal usage involves headshots on standard enemies (one-shot kill after 3 damage upgrades) and weak point targeting on bosses. The slow fire rate requires accuracy over spray making it unsuitable for crowd control without positioning. Pair with Shotgun for close-range encounters.

Requiem Revolver Stats

Grace's Blood Specimen Crafting System

Blood Specimen crafting is Grace's unique mechanic enabling creation of special ammunition and injectors from enemy blood samples. The system requires collecting Blood Vials from defeated enemies with different enemy types yielding different specimen qualities. Standard enemies drop Common Vials while bosses drop Rare Vials.

Crafting stations located in Safe Houses enable specimen processing into usable items. The system requires Chemical Reagents found throughout levels combined with Blood Vials for successful crafting. Failed crafts waste materials requiring careful resource management.

Craftable items include Blood Explosives (area damage), Hemolytic Injectors (chain damage), Coagulant Darts (enemy slowdown), and Hemorrhage Bullets (damage over time). Each item serves specific tactical purposes enabling flexible loadout customization for different encounter types.

Blood Specimen Recipes

How to Unlock Hemolytic Injectors

Hemolytic Injectors unlock in Chapter 10 Blood Laboratory after completing the Specimen Analysis quest line. The quest requires collecting 10 Rare Blood Vials from elite enemies throughout Chapters 7-9 before laboratory access. Missing Vials requires backtracking to previous chapters through Chapter Select.

Elite enemy locations include Chapter 7 Laboratory Guards (3 Vials), Chapter 8 Warehouse Hunters (4 Vials), and Chapter 9 Elite Soldiers (3 Vials). All enemies must be defeated with melee attacks to preserve Vial quality as firearm damage destroys blood samples. This requirement challenges combat approach significantly.

Once unlocked, Hemolytic Injectors deal 200 base damage with chain explosion spreading to nearby enemies. The chain effect hits up to 5 enemies within 3-meter radius making it ideal for crowd control. Ammunition capacity is 6 injectors per craft with 10 maximum carry capacity.

Hemolytic Injector Quest Steps

Leon's Mortal Edge Axe (Challenge Run Key)

The Mortal Edge Axe is Leon's signature melee weapon located in Chapter 5 Ancient Shrine before the collapsing sequence. The weapon deals 800 damage per swing with one-hit kills on standard enemies after 2 damage upgrades. The axe is essential for "Axe-Only" challenge runs and S+ rank speedruns on Professional difficulty.

Missable window is approximately 8 minutes from shrine entry to collapse with no return possible after sequence. Chapter Select unavailable for Leon's campaign requiring full replay if missed. Set waypoint marker immediately upon shrine entry preventing accidental skip.

Upgrade path includes Damage (5 levels), Swing Speed (3 levels), Durability (3 levels), and Unbreakable (NG+ only). Total upgrade cost is 200,000 Gold for full upgrades before unbreakable unlock. The investment is essential for challenge run viability.

Mortal Edge Axe Stats

All Weapon Upgrade Locations

Weapon upgrades purchased from Merchant NPCs located in Safe Houses throughout both campaigns. Grace has 8 Merchant locations while Leon has 7 with overlapping chapters sharing Merchant access. Upgrade availability depends on campaign progression with higher tiers unlocking in later chapters.

Gold currency earned through enemy drops, treasure collection, and challenge completion. Average playthrough yields 400,000-500,000 Gold enabling 2-3 fully upgraded weapons per campaign. Prioritize primary weapons before secondary for efficient resource allocation.

Treasure maps located in Chapters 3, 6, and 9 reveal hidden gold caches worth 50,000-100,000 Gold each. The maps are missable without thorough exploration requiring backtracking for completionists. Chapter Select (Grace only) enables returning for missed treasures.

Merchant Locations

Ammunition Crafting Recipes

Ammunition crafting enables resource management through chemical and material combination at Safe House workbenches. Both characters share identical recipes with character-specific ammunition types for unique weapons. Crafting efficiency improves with Chemical Expertise upgrade reducing material requirements.

Common materials include Gunpowder (enemy drops), Chemicals (environmental pickups), and Metal Scraps (container breaks). Material spawn rates remain consistent across difficulty settings enabling reliable farming routes. Speedrunners memorize optimal farming paths for efficient crafting.

Crafting priorities should focus on primary weapon ammunition before secondary weapons. Handgun and rifle ammunition provide best damage-per-material ratios for general encounters. Special ammunition (explosive, incendiary) reserved for boss encounters and elite enemies.

Ammunition Crafting Recipes

Missable Weapons and Points of No Return

Two missable weapons exist in Resident Evil Requiem: Grace's Requiem Revolver (Chapter 8) and Leon's Mortal Edge Axe (Chapter 5). Both weapons require collection before specific story triggers with no return possible after progression. Chapter Select available for Grace only requiring Leon players to full replay for misses.

Point of No Return occurs at Chapter 11 for both campaigns with final area locking previous locations. All collectibles and weapons must be acquired before Chapter 11 entry. The game provides clear warning before point of no return enabling final preparation.

Completionist checklist should verify all weapons collected before Chapter 11. Merchant inventory should be fully purchased preventing gold waste. Crafting materials should be converted to ammunition maximizing resource efficiency before final chapters.

Missable Weapon Checklist

What Market Impact Could This Have?

Option A: Competitive Comparison

Weapon guide content drives consistent long-tail search traffic for months post-launch with Resident Evil titles historically generating 200,000+ weapon guide searches within first 3 months. Early publishers capture majority of this traffic with later articles receiving diminishing returns. Evergreen nature enables sustained traffic versus news content.

Video walkthroughs compete with written guides but many players prefer text for quick weapon location reference. The format enables faster information scanning without video scrubbing. Both formats complement each other capturing different user preferences.

SEO competition increases for major franchise releases with established gaming sites dominating early search results. Independent publishers can compete through specificity and faster publishing speeds. Niche weapon guides often outrank general launch guides for specific queries.

What Risks and Limitations Should Players Consider?

Option B: OEM / Ecosystem / Market Impact

Guide usage eliminates discovery satisfaction reducing organic exploration rewards. The tension from finding weapons naturally represents core survival horror appeal. Consider attempting weapon hunting independently before consulting guides for optimal experience.

Spoiler exposure risks extend beyond weapon locations with guide content revealing story progression points. Chapter 8 and 11 spoilers particularly impactful for first-time players. Verify content boundaries before reading if spoiler-sensitive.

Upgrade resource allocation affects playthrough difficulty with poor choices creating unnecessary challenge. First-time players should prioritize damage upgrades before capacity for efficient progression. Guide recommendations optimize resource efficiency reducing trial-and-error frustration.

What Are the Pros and Cons of Each Weapon Type?

Revolvers: High damage, excellent accuracy, slow fire rate, limited capacity. Best for: Precision shots, boss weak points, ammunition efficiency.

Assault Rifles: Moderate damage, high fire rate, good accuracy, large capacity. Best for: Crowd control, medium range, versatile engagements.

Shotguns: Very high close damage, low range, slow reload, limited capacity. Best for: Close quarters, door camping, emergency situations.

Melee: No ammunition, very close range, variable damage, durability concerns. Best for: Stealth kills, resource conservation, challenge runs.

Special Weapons: Unique effects, limited ammunition, high resource cost, situational use. Best for: Specific encounters, crowd control, boss fights.

Which Weapons Should You Prioritize?

Best Use Cases / Buyer Guidance:

First-time players should prioritize Requiem Revolver (Grace) or Mortal Edge Axe (Leon) for primary weapon investment. The damage output enables efficient enemy elimination reducing ammunition consumption. Secondary weapons should receive minimal upgrades until primary weapons maxed.

Speedrunners should prioritize movement speed upgrades and infinite ammunition unlocks for NG+ runs. The time savings from reduced resource management exceeds damage upgrade value. Route optimization depends on weapon availability timing.

Challenge run players should verify weapon requirements before starting specialized runs. Axe-only and pistol-only runs have specific weapon requirements affecting upgrade allocation. Planning prevents wasted resources on incompatible upgrades.

Affiliate Note: Resident Evil Requiem available at $69.99 USD across PC, PS5, Xbox Series X|S, and Switch 2. All weapons accessible without DLC purchases. Upgrade resources earned through gameplay not microtransactions.

What Non-Obvious Insights Matter for Players?

Weapon damage upgrades provide better value than capacity upgrades for most playstyles. The one-shot kill threshold reductions enable ammunition conservation exceeding capacity benefits. Mathematical optimization favors damage for resource efficiency.

Merchant inventory refreshes after boss defeats enabling additional upgrade purchases. Players should revisit Merchants after major encounters for newly available upgrades. The mechanic enables progressive upgrade paths matching campaign difficulty scaling.

Missable weapons affect achievement eligibility for completionist trophies. The "Arsenal" achievement requires all weapons collected in single playthrough. Chapter Select enables Grace completion but Leon requires careful first playthrough.

Frequently Asked Questions

Final Verdict: Best Loadout for Each Campaign

Grace's optimal loadout includes Requiem Revolver (primary), Shotgun (close range), Hemolytic Injectors (crowd control), and Sniper Rifle (long range). The combination covers all engagement distances with ammunition efficiency through revolver primary. Blood Specimen crafting supplements ammunition for extended exploration.

Leon's optimal loadout includes Mortal Edge Axe (melee), Assault Rifle (medium range), Dragon Breath Magnum (bosses), and Rocket Launcher (emergency). The combination enables flexible combat approaches with axe conserving ammunition for difficult encounters. Flamethrower provides alternative crowd control option.

First-time players should focus on primary weapon upgrades before diversifying loadouts. The damage thresholds enable efficient progression without resource waste. NG+ players should experiment with specialized loadouts for challenge runs and speedrun categories.

Key Takeaways

• Requiem Revolver (Grace) and Mortal Edge Axe (Leon) are best weapons
• Both weapons are missable requiring careful chapter progression
• Blood Specimen crafting enables Grace's unique ammunition types
• 24 total weapons across both campaigns with 12 per character
• Infinite ammunition unlocks in NG+ through Challenge Point purchases